Preheat oven to 350 °F (177 °C) and line baking sheets with parchment paper or silicone baking mats.
In a large bowl, whisk together flour, baking soda, baking powder, pumpkin pie spice, and salt. Set aside.
2 cups all purpose flour, 3/4 teaspoon baking soda, 1/4 teaspoon baking powder, 1 tablespoon pumpkin pie spice, 1/4 teaspoon salt
In the bowl of a stand mixer fitted with the paddle attachment, cream together butter and sugars until light and fluffy. Next, add the egg and vanilla extract and mix until incorporated.
8 tablespoons unsalted butter, 3/4 cup granulated sugar, 1/2 cup dark brown sugar, 1 egg, 1 teaspoon vanilla extract
Add the pumpkin puree and peanut butter and beat until mixed well. Then gently add in the flour mixture in two batches.
1 cup pumpkin puree, 3/4 cup creamy peanut butter
Spoon dough onto cookie sheet with a cookie scoop.
Bake for 10-12 minutes or until edges start getting golden brown and the cookie is just starting to set.
Let cool on baking sheet for 5 minutes before transferring to a wire cooling rack to cool completely.